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更新时间:2020-10-27 16:39

Dr. Bi-Sen Ding is a distinguished investigator at Sichuan University. He received his bachelor from Nanjing University and Ph.D. in Pharmacology from the University of Pennsylvania. His research aims to uncover microenvironmental regulation of organ regeneration and fibrosis. During his Ph.D. study at PENN and postdoc research at Howard Hughes Medical Institute/Cornell University, he elucidated that vascular endothelial cell produces paracrine factors to instruct liver and lung regeneration and repair, functionalizing a "vascular niche". These findings were published with him as first author in journals such as “Cell”, “Nature”, “Blood”, and Circulation”. Dr. Ding initiated his independent research as tenure track Assistant Professor at Cornell in 2013. Since then, his lab has uncovered that the pro-regenerative cues from vascular endothelial cell can be subverted to promote fibrosis or tumorigenesis. Therapeutic targeting of this “maladaptive vascular niche” can enable clinical strategy to promote organ regeneration and to block fibrosis and tumorigenesis. His ongoing research has further demonstrated that perivascular hematopoietic and fibroblast cell regulate the vascular niche in a divergent manner, differentially promoting either regeneration or fibrosis/tumorigenesis in injured organs. These findings are published in Nature”, “Cancer Cell, Nature Cell Biology”, “Nature Medicine”, “Science Translational Medicine, and “Developmental Cell” communicated as corresponding author.